BUBR1 IS FREQUENTLY REPRESSED IN ACUTE MYELOID LEUKEMIA AND ITS RE-EXPRESSION SENSITIZES CELLS TO ANTIMITOTIC THERAPY

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds Gift Cards well.In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast majority of cases of acute myeloid leukemia whereas its expression was high in lymphoblastic

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Linked-evidence modelling of qualitative G6PD testing to inform low- and intermediate-dose primaquine treatment for radical cure of Plasmodium vivax.

BackgroundRadical cure of Plasmodium vivax infections is key to the control of vivax malaria.However, the standard doses of 8-aminoquinoline drugs used for radical cure can cause severe haemolysis in G6PD-deficient patients.The availability of near-patient G6PD tests could increase use of primaquine (PQ), however direct evidence of the impacts that

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